I have exactly the same problem but with Kapersky, see here:
http://www.pogoplugged.com/forum/thread/14149/Problems-Using-PogoDrive-with-M...
I've been using and loving my PogoPlug for about 2 months.
Not sure when this behavior started, but I can no longer open Word documents on the PogoPlug. I can open a local file and save to the device but if I try to open a document, it hangs hard (hoses network stack and need to powercycle).
Configuration (don't laugh)...
Windows 7 rc
Office 2007
PogoPlug 1.0.0.16
NOD32 v4 anti-virus
If I disable NOD32, I can open files -- so something about how NOD32 hooks into drive letters or Word no doubt. I'm posting the same message in the NOD32 forums, but I'm guessing they are less worried about PogoPlug interactions than you are.
Thanks,
Joe

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